KCNH2 and torsades de pointes: Concomitant medications in reported cases included sotalol, nintedanib, methadone, amitriptyline, fluoxetine, clonazepam, and alprazolam, etc., [37], which are known to have direct effects on cardiac ion-channels (e.g., hERG) and may induce long QT and TdP in humans by themselves.