Given that the regulation of STEP has been implicated in the pathophysiology of a number of neurological and neuropsychiatric disorders [12], the interaction between A2AR and mGlu5R in the modulation of STEP activity appears to be particularly interesting since it could have a role in brain diseases [33] and could be involved in the therapeutic effects of A2AR and mGlu5R antagonists. The gene discussed is ADORA2A; the disease is brain disorder.