Notably, an IgG4/IgG1 ratio > 0.05 and a serum IgG4 concentration > 700 mg/dL were linked to a considerably higher 30-day death rate, and serum IgG4 concentration was significantly associated with levels of IL-6 [15], a recognized forecaster of COVID-19-linked mortality [16,17,18] whose synthesis is induced by the open reading frame protein 8 (ORF8) of SARS-CoV-2 [19]. The gene discussed is IL6; the disease is COVID-19.