HMGB1 and non-small cell lung carcinoma: Therefore, our data are consistent with the concept that LMB-mediated accumulation of HMGB1 in the nucleus facilitates the known ability of HMGB1 to inhibit 1,2-(GpG) DNA intrastrand repair [4,58,59,60] and so potentiates the ability of cisplatin to induce A549 NSCLC viability and cell death (Figure 7).