ABCD1 and X-linked adrenoleukodystrophy: Furthermore, a recent whole-transcriptome analysis conducted on Abcd1-deficient BV-2 cells, a murine microglial cell model for X-ALD, revealed similar differences in cholesterol-related gene expression, with Soat1, Nceh1, Apoe and other genes related to the cholesterol efflux being significantly upregulated in mutant vs. WT BV-2 cells [63].