In view of the arguments and evidence presented here, it is suggested that a combination of corticosteroids and/or anti-IL-6 and anti-TNF-α antibodies and GLA, DHLA, AA, EPA, DHA, along with vitamins C, B1, B6, B12, and folic acid, can prevent and suppress sepsis and other inflammatory conditions. The gene discussed is TNF; the disease is Sepsis.