Inflammatory factors, such as tumor necrosis factor alpha (TNF-α), interferon gamma (INF-γ), interleukin-1 (IL-1), and interleukin-6 (IL-6), which are released by immune or tumor cells, promote proteolysis in skeletal muscle and suppress protein synthesis through the intracellular signaling pathways [10,11,12]. This evidence concerns the gene IL6 and neoplasm.