Studies have shown that PWS has anti-inflammatory effects in dextran sulfate sodium and Clostridium difficile-induced IBD mouse models via restoration of mucus thickness, tight junctions, and microbiota ratio [7] and in lipopolysaccharide-challenged RAW264.7 cells by decreasing prostaglandin E2, nitric oxide, interleukin 6, and tumor necrosis factor (TNF) alpha [8]; however, the specific mechanism of PWS in IBD is unclear. The gene discussed is TNF; the disease is inflammatory bowel disease.