BGLAP and Duchenne muscular dystrophy: Figure 2 portrays the integrative physiology of muscle, bone, and adipose. DMD is associated with low bone mineral density and bone fractures—bone dystrophy [143], which is exacerbated by the use of corticosteroids. In contrast, DMD patients treated with vamorolone show normal bone growth and increase in or normal serum osteocalcin; a bone formation biomarker [113,144]. So far, the use of bisphosphonates to prevent bone loss in DMD patients has not been investigated in clinical trials [102].