The enrichment plots revealed that gene signatures related to Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Systemic lupus erythematosus, Allograft rejection, Leishmania infection, ECM receptor interaction, Complement-and-coagulation cascades, Autoimmune thyroid disease, and Jak-Stat signaling pathway were activated in patients with high TRIM6 expression (Figure 6A). The gene discussed is TRIM6; the disease is autoimmune thyroid disease.