PLK1 and central nervous system cancer: We further analyzed the correlation between TRIM6 and the cell cycle regulation genes in TCGA-Gliomas, and we found that the expressions of the cell cycle regulatory genes CCNA2, CCNB1, CCNB2, CCNE1, CHEK1, BUB1B, ESPL1, PTTG1, PCNA, PKMYT1, CDC45, PLK1, MCM2, MCM4, MCM6, E2F1, CDC6, CDC20, CDC25A, and CDC25C were positively correlated with TRIM6 (r > 0.3, p < 0.001) (Figure 11A–J).