COL1A1 and central nervous system cancer: The results revealed that high expression of nine hub genes, namely COL1A1, COL1A2, CXCL8, CXCL9, CXCL10, CXCL11, CXCR3, MMP9, and TIMP1, was associated with worse survival outcomes among Glioma patients (Figure 8A–I).