The results showed a significant upregulation of COL1A1, COL1A2, CXCL8, CXCL9, CXCL10, CXCL11, CCL11, CXCR3, MMP9, and TIMP1 mRNA expression levels in the glioma tumor tissues compared to the adjacent non-tumor tissues (Figure 7D). This evidence concerns the gene MMP9 and central nervous system cancer.