NR3C1 and cancer: Given the fact that in the last four decades clinicians have administered synthetic glucocorticoids such as dexamethasone and prednisone, along with chemotherapy to relieve the latter’s side effects and make it tolerable to cancer patients, it is of paramount importance to elucidate their GR-mediated effect on cancer cells and to clarify whether their co-administration with chemotherapy is safe and effective.