Jeon et al. discovered that dexamethasone inhibits the apoptotic process triggered by the tumor necrosis factor (TNF)-related apoptosis-inducing ligand via the glycogen synthase kinase-3beta (GSK-3β)-mediated downregulation of death receptor 5 and the upregulation of cellular FLICE-inhibitory protein (FLIP) in A549 lung adenocarcinoma cells [28]. This evidence concerns the gene GSK3B and lung adenocarcinoma.