TARDBP and amyotrophic lateral sclerosis: TDP-43 can also be subjected to post-translational modifications, and in particular, phosphorylated TDP-43 (pTDP-43) is considered a marker of the disease and used as a diagnostic tool to identify TDP-43-positive protein inclusions in the brain and spinal cord of ALS and FTD patients [57,58,59,60].