PRMT1 and Parkinson disease: In line with this evidence, the expression of PRMT1 was elevated in the SNpc of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice, and PRMT1 haploinsufficiency (prmt1 +/−) was correlated with reduced death of dopaminergic neurons in vivo, indicating the potential critical role of PRMT1 in the apoptosis of dopaminergic neurons in PD [76].