Interestingly, unlike what was observed for the sEV population, in the acute COVID-19 patients, the increased lEV levels were paralleled by an increase in TF-dependent FXa generation when compared to the HSs (αTF-neutralizing antibody effect: 14.7 ± 1.1 pM/mL and 4.2 ± 0.7 pM/mL in acute COVID patients and HSs, respectively; p = 0.001). Here, TF is linked to COVID-19.