MYCN and neuroblastoma: MYCN upstream regulators, such as TP53, TERT, ODC1, MCM7, and MDM2, the MYCN downstream targets KIFAP3, OPHN, RGS7, TOP2A, TWIST1, and TYMS [4], the proliferation inductor ALK [5] and microRNAs, such as the miR-17-92 cluster [6,7], and the miR-181 family, miR-542-5p, and miR-628 [6] are also key players in the development of neuroblastoma.