NLRP3 and acute kidney injury: Of note, the finding that Nlrp3 knockout regulates renal metabolism-related pathways, including steroid hormone metabolism, is an innovation of our study, which supports that we should pay attention to the adrenal function of patients with S-AKI in clinical practice and that, in addition to energy metabolic rewiring, multiple substance metabolism is also involved in the pathogenesis of S-AKI.