While prior research has demonstrated elevated NLRP3 in the kidneys of S-AKI models as well as in the serum of patients with sepsis and the significant involvement of the NLRP3 inflammasome in the progression of S-AKI [8,13,24,25], there is currently no reported study on the expression of NLRP3 in renal tissues of S-AKI patients. This evidence concerns the gene NLRP3 and Sepsis.