Deleterious mutations in the genes of NPPA [94], GJA5 [95,96,97], GJC1 [65], TBX5 [98,99,100], GATA4 [101,102,103], GATA5 [104,105], NKX2-5 [106,107,108], and KCNH2 [76] have been discovered to be accountable for AF. The gene discussed is KCNH2; the disease is atrial fibrillation.