Notably, in humans, multiple TBX20 mutations have been discovered to give rise to various congenital heart defects, encompassing atrial/ventricular septal defects, Fallot’s tetralogy/pentalogy, common atrioventricular canals, double outlets of the right ventricle, aortic coarctation, patent ductus arteriosus, abnormal pulmonary vein connections, and cardiac valve malformation, as well as dilated cardiomyopathy [133,134,135,136]. This evidence concerns the gene TBX20 and dilated cardiomyopathy.