APLN and cancer: However, the DEGs in cluster 4 were mainly enriched in KEGG pathways related to cell proliferation, differentiation and migration (MAPK signaling pathway, pathways in cancer, hippo signaling pathway, FoxO signaling pathway, chemokine signaling pathway, apelin signaling pathway, oxytocin signaling pathway, tight junction, bladder cancer, AMPK signaling pathway, linoleic acid metabolism, nonsmall cell lung cancer, and longevity-regulating pathway).