PKA-mediated Rpn6 phosphorylation was found to induce an increase in proteasome activity and stimulate the degradation of aggregation-prone proteins such as tau, TDP-43, and FUS (fused in sarcoma), an RNA binding protein involved in ALS and frontotemporal dementia (FTD) [84]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.