NOS2 and intestinal cancer: As chronic activation of some inducible enzymes, such as iNOS and COX-2, plays pivotal roles in the development of certain inflammatory diseases that may initiate the oncogenesis process, and the use of anti-inflammatory drugs, such as aspirin, is proposed to prevent inflammation-associated carcinogenesis [35,36], both CON and OOP peptides were used to treat two lines of human intestinal cancer cells to highlight a putative positive effect on cell proliferation and differentiation.