The metabolomic approach to determine a genetic modifier in an FXTAS mouse model found metabolic changes and demonstrated that Schlank (ceramide synthase), Sk2 (sphingosine kinase), and Ras (IMP dehydrogenase), which encode enzymes in the sphingolipid and purine metabolism, respectively, were significantly related with FXTAS-CGG-associated neurodegeneration pathogenesis [149]. This evidence concerns the gene TLCD3B and fragile X-associated tremor/ataxia syndrome.