IL-1β and IL-18 promote the differentiation of naïve CD4+ T cells in effector, pro-inflammatory T helper 1 (Th1) cells and Th17 cells, which are mainly responsible for the T cell-driven injury of corneas, conjunctiva, lacrimal, and meibomian glands in patients suffering from severe keratitis, uveitis, conjunctivitis, and DED [15]. This evidence concerns the gene IL1B and uveitis.