Since MAM dysfunction plays an important role not only in Ca2+ signaling [87] but also in the protection against ER [88] or oxidative stress [89], lipid metabolism [90], and cell survival [91], TRPV1 could be an exciting target to prevent or restore MAM coupling in several pathological contexts ranging from metabolic disorders [92] to neurodegenerative diseases [93] and cancer [94]. This evidence concerns the gene SGCG and cancer.