Paradoxically, TRPV1 activation restores the ER–mitochondrial tethering by increasing the expression of a MAM protein named phosphofurin acidic cluster sorting protein-2 (PACS2) in pulmonary fibrosis [32] or else favors MAM formation through the AMPK-MFN2 pathway in response to myocardial hypertrophy [33]. Here, TRPV1 is linked to cardiac hypertrophy.