During the course of these proteinopathies, beta-amyloid (Aβ) aggregates in AD, inclusions of hyperphosphorylated microtubule-binding tau in AD and other tauopathies, aggregates of α-synuclein in PD and other synucleinopathies, and inclusions of TAR DNA-binding protein (TDP)-43 in case of ALS occur. Here, TARDBP is linked to proteostasis deficiencies.