An autophagic receptor/adaptor like p62 is involved in the aggregation of Aβ, tau in the case of AD [153], α-synuclein in the case of PD [154], TDP-43 [155], and SOD1 in the case of ALS [156]; whereas optineurin (OPTN) is involved in the aggregation of tau in the case of AD and SOD1 and TDP-43 in the case of ALS. This evidence concerns the gene SOD1 and Alzheimer disease.