These radicals can act as a determinant to trigger the biochemical conformational trajectories via changing the cellular redox thiol (SH) status of several proteins leading to misfolding and toxic proteinopathies in NDDs like amyloid β in AD [50,51], α-synuclein in PD [52,53] and SOD1 [54,55,56], and TDP-43 in case of ALS [54,57,58]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.