MAPT and Alzheimer disease: The aggregation of neurotoxic proteins in NDDs, like amyloid-β (in case of AD) [204], tau (in case of AD) [204], α-synuclein (in case of PD), mSOD1 (in case of ALS), and TDP-43 (in case of ALS), initiates changes to induce both microglia and astrocytes to produce harmful pro-inflammatory pathological phenotypic biomarkers.