The expression of MCPIP1 shRNA or FLAG-MCPIP1 (D141N) in the NPC cells, resulting in the elevation of let-7g, caused the loss of KRAS-modulating glycolysis and mitochondrial respiration functions; however, FLAG-MCPIP1 overexpression led to the decline of let-7g, facilitating KRAS-mediated glycolysis and mitochondrial respiration activities. Here, KRAS is linked to nasopharyngeal carcinoma.