The overexpression of the negative (N) mimic control did not influence the signaling and metabolic parameters of NPC cells, whereas let-7g mimic expression downregulated KRAS expression and caused impacts similar to those of NGN on the decreased levels of p-Akt (Ser 473), GTP-Rac1, mitochondrial OCR, ECAR, glucose uptake, intracellular glucose, pyruvate, lactate, and ATP (Figure 4F–O and Supplementary Tables S3 and S4). The gene discussed is RAC1; the disease is nasopharyngeal carcinoma.