To determine if ROS-initiated DNA damage may cause neurodevelopmental disorders in part via epigenetic mechanisms, we measured OGG1- and EtOH-dependent (1) changes in epigenetic histone protein and DNA modifications, (2) altered expression of representative genes involved in epigenetic regulation and neurodevelopment, (3) involvement of candidate locus Esr1 and (4) neurodevelopmental disorders using a battery of behavioural tests. The gene discussed is ESR1; the disease is neurodevelopmental disorder.