In the regulation of the DNA damage response, both RUNX1 and RUNX3 form a complex with p53 and promote the transactivation of p53 target genes (BAX, PUMA, NOXA, and p21), whilst the interaction of RUNX2 with p53 suppresses the transactivation of p53 target genes such as p21, WAF1, and BAX [167], so the potential SL interaction between p53 and RUNX genes in HCC requires further investigation. The gene discussed is RUNX3; the disease is hepatocellular carcinoma.