Chromosomal rearrangements, like translocations, t (8; 21), t (3; 21), and t (12; 21), which form fusion proteins of RUNX1 protein part with another protein, such as ETO, EVI1, and ETV6, are common in AML, CML and ALL, prevalently influencing loss of function [28,29,30]. The gene discussed is RUNX1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.