Recently, Hamczyk et al. (2018) produced the first mouse model (Apoe–/–LmnaLCS/LCSSM22αCre) with progerin-induced atherosclerosis acceleration expressing progerin specifically in VSMCs and demonstrated that restricting progerin expression to VSMCs is sufficient to accelerate atherosclerosis, trigger plaque vulnerability, and reduce lifespan [66]. Here, APOE is linked to atherosclerosis.