The UMAP plots with specific markers (ESR1, PGR, and ERBB2 as breast cancer markers, KRT5 as a basal marker, ACTA2 as a myoepithelial marker, and MKI67 as a proliferation marker) are shown in Figure 2C. The expression of ESR1 and ERBB2 was diffusely distributed on each cluster but the intensities were different among each cluster (Figure 2D). This evidence concerns the gene ESR1 and breast cancer.