ESR1 and breast carcinoma: The UMAP plots with specific markers (ESR1, PGR, and ERBB2 as breast cancer markers, KRT5 as a basal marker, ACTA2 as a myoepithelial marker, and MKI67 as a proliferation marker) are shown in Figure 2C. The expression of ESR1 and ERBB2 was diffusely distributed on each cluster but the intensities were different among each cluster (Figure 2D).