Immunotherapy, as a valuable approach against cancer, was further confirmed by other findings; in fact, Wölfl and colleagues showed that it is possible to provoke a widespread expansion of antigen-specific T cells using purified naïve CD8+ T cells in combination with ILs such as IL-21, IL-7, and IL-15 in human glioblastoma samples [112]. This evidence concerns the gene IL21 and glioblastoma.