Genetic abnormalities of the IDH1 coding gene are also frequent in glioblastoma; these mutations reduce the affinity of the active site of IDH1 for isocitrate while conversely increasing the affinity for nicotinamide adenine dinucleotide phosphate (NADPH) and α-ketlutogarate (α-KG) [47]. This evidence concerns the gene IDH1 and glioblastoma.