It has been shown that in UGT1A1 knocked-out mice, Toll-like receptor 2 (TLR2) is required for regulating gliosis, pro-inflammatory mediators, and oxidative stress when neonatal mice are exposed to severe hyperbilirubinemia, but TLR2 also has anti-apoptotic properties. The gene discussed is TLR2; the disease is Hyperbilirubinemia.