In an ApoE-/- atherosclerosis mouse model, exosomal delivery of small interfering RNA against LOC100129516 decreased total cholesterol and low-density lipoprotein levels through activation of the peroxisome proliferator-activated receptor γ (PPARγ)/liver X receptor α (LXRα)/phospholipid-transporting ATPase ABCA1 (ABCA1) signaling pathway, promoting cholesterol efflux and suppressing intracellular lipid accumulation [74]. The gene discussed is ABCA1; the disease is atherosclerosis.