AIF1 and Alzheimer disease: To characterize the in situ activation of both microglial phagocytosis and migration processes in this AD model, the coexpression of two microglia markers was assessed in the CA1 hippocampus of 2m-, 6m- and 12m-Tg-m by double immunostaining of Iba1 and CD68, which selectively marks the presence of phagocytic vesicles.