APC and colonic neoplasm: Activation of mTORC1 by APC truncations is clearly evident in zebrafish embryos with the homozygous apcmcr/mcr mutation [94], in adenomas from mice with the Apcmin mutation [80], in sporadic colonic adenomas and colon cancer in humans [137,138,139], and in adenomas from patients with FAP (Figure 3).