In addition, it is widely demonstrated in the literature that following different brain insults (e.g., hypoxia, ischemic damage, neurodegenerative diseases, toxicity), PK2 and PKR2 are usually overexpressed by both neurons and astrocytes in specific hippocampal areas and in cortical neuron cultures [78,79,80,81]. The gene discussed is PROK2; the disease is neurodegenerative disease.