MAPT and tauopathy: NAP replaces/repairs these deficiencies by working as a crucial ADNP fragment that enhances microtubule dynamics and Tau–microtubule interactions [36], protecting against Tau hyper-phosphorylation [34,37] and tauopathy [10,34], regulating actin–cytoskeletal association [3], and linking with WNT signaling [16,38] to lead to dendritic spine formation [10,33,35], which translates to normalized development and behavioral protection [34,35,39].