The Tet-on system [173] induced rapid liver enlargement and tumorigenesis, which often progressed to hepatocellular carcinoma (HCC) with various oncogenes such as CTNNB1mt and tcf7l2 [174], krasV12 [175], HCP [176], xmrk [177], and mouse Myc [178]. The gene discussed is MYC; the disease is hepatocellular carcinoma.