Beyond female cancers, as a number of genes in our BRCA signatures had previously emerged as cancer genes in males—for example, RGN, a calcium regulator found to be a TS in prostate cancer (PrCa), and COL4A6, whose downregulation and hypermethylation is linked to progression and metastasis of PrCa (Table S1)—we suggest that further investigation of our listed genes is warranted, in cancers of both reproductive and non-reproductive organs of males and females. Here, RGN is linked to Familial prostate cancer.