Several prime examples are functionally linked to metabolism: monoamine oxidase A (MAOA) inhibits aerobic glycolysis and immunity in lung cancer [49]; Integral Membrane Protein 2A (ITM2A) in BRCA induces PD-1 and higher tumour infiltrating lymphocyte (TIL) infiltration [50]; and GRB2-associated binding protein 3 (GAB3) drives natural killer cell priming and expansion [51]. Here, ITM2A is linked to lung cancer.