Of note, the tumour suppressors KDM5C and KDM6A have been previously identified to play fundamental roles in cancer sex-disparity, as they escape XCI to retain their function when mutated [11], while ZRSR2 mutations/loss have been associated with sex-disparity in blood cancers [41]. The gene discussed is ZRSR2; the disease is hematopoietic and lymphoid system neoplasm.