The autoantibody generation, still a not-fully described topic, and the increased levels of autoantibodies’ anti-CCP in RA patients have been reported; likewise, increased proinflammatory cytokine levels have been informed among patients with positive autoantibodies vs. negative in individuals with RA, such as the interleukin 6 (IL-6, up to 4-fold) [37]. Here, IL6 is linked to rheumatoid arthritis.