Lending support to Sp1-GPER cross-talk, the analysis of the GSE17498 dataset revealed an inverse correlation between GPER1 and Sp1 mRNA levels in MM patients (Figure 4B); furthermore, in agreement with these findings, G-1 treatment resulted in GPER upregulation, while reducing Sp1 protein expression, in NCI-H929 cells (Figure 4C). Here, GPER1 is linked to Miyoshi myopathy.