Since initial reports that circulating tumor necrosis factor receptors 1 and 2 (cTNFR1/2) elevations predict diabetic nephropathy progression [1,2], numerous studies have demonstrated that cTNFR1/2 level increases correlate with the severity and progression of CKD of any cause examined (e.g., in additional diabetic nephropathy populations, idiopathic membranous nephropathy, IgA nephropathy, lupus nephritis, and hypertension-related nephropathy [3,4,5,6,7,8,9,10,11,12]). This evidence concerns the gene TNFRSF1A and diabetic kidney disease.