FLT3 and acute myeloid leukemia: Further, inhibition of depalmitoylation with palmostatin B (palm B), a pan-depalmitoylase inhibitor, not only reduced proliferation of FLT3-ITD+ AML cells but also synergized FLT3-ITD+ AML cells to gilteritinib, a FLT3 kinase inhibitor, treatment.