Piezo2 is mainly expressed in sensory tissues, such as dorsal root ganglion (DRG) sensory neurons and Merkel cells,[41] and regulates mechanical nociception.[42] Previous studies have found that Piezo1 acts as an important regulator of bone remodeling, regulating both osteoblast lineage cells and osteoclasts in osteoporosis.[24, 43] However, the specific target cells of Piezo1 remain unclear in DOP. This evidence concerns the gene PIEZO1 and osteoporosis.