APOE and Alzheimer disease: The results from study on AD transgenic mouse model revealed brain region‐specific deposition of GM1 in hippocampal and cortical amyloid plaque.[27] It was also shown that aging and apoE4 expression accelerates Aβ aggregation through the increase and regulation of GM1 distribution in neuronal membranes.[17] These findings suggest that higher concentrations of GM1 may be associated with AD.