MRE11 and ovarian serous adenocarcinoma: To further clarify the specificity of acquired MRE11:p.K464R mutation, we mined four serous ovarian cancer datasets in cBioportal database (www.cbioportal.org) [20, 21] and found that the variants of MRE11 gene had been rarely reported in previous studies, with a mutation frequency of about 5% in the population, and only four patients had mutations in MRE11 (Fig. 1C).