The emergence of MRE11:p.K464R mutation leads to the enhancement of DNA damage repair, blocking the accumulation of DNA damage and subsequent tumor cell death, which may lead to the generation of multiple drug resistance of tumor cells, including platinum resistance, PARP inhibitor resistance, antibiotic resistance, etc., suggesting that MRE11:p.K464R mutation may be a common mechanism of resistance to cancer drugs. The gene discussed is MRE11; the disease is cancer.