MRE11 and ovarian cancer: In order to further clarify the functional phenotype of Olaparib resistance caused by MRE11:p.K464R mutation, we selected two ovarian cancer cell lines (SKOV3 and A2780) and generated stable cell lines expressing MRE11WT and MRE11K464R protein (Fig. 3A and B) after MRE11 knockout (Fig. S1A and S1B), respectively.