CYP3A4 and familial hypercholesterolemia: For example, Kajinami et al. showed that after 52 weeks of atorvastatin therapy (10 mg/day), the A-290G mutant allele of CYP3A4 (CYP3A4*1B) was related to increased levels of LDL-C in 340 American subjects with hypercholesterolemia (P<0.05) [24, 34, 35].