Moreover, women who developed PPD after delivery have elevated CRH levels in mid-pregnancy, and the severity of PPD positively correlates with CRH levels, compared to women who did not develop PPD after delivery, however, ACTH, another protein in the HPA axis, was not correlated with PPD [78, 79]. The gene discussed is POMC; the disease is progressive pseudorheumatoid arthropathy of childhood.