Colorectal and endometrial cancer-derived fibroblasts were reported to inhibit NK cell activity via the downregulation of NK cell activation receptors (CD69, NKG2D, DNAM-1, NKp30, NKp44, and CD27) and cytolytic granules (perforin and granzyme B), suggesting that this characteristic of CAFs is not limited to pancreatic carcinoma [59–61]. This evidence concerns the gene NCR2 and exocrine pancreatic carcinoma.