Very few glaucoma-related neuroinflammatory and reactive astrocyte genes and pathways were differentially expressed (Hsp70, Hsp90, Hspb1, C2, Tlr4, S100b, Lcn2, H2-T23), and understanding their significance to an overall neuroinflammatory astrocyte requires more focused functional testing. Here, TLR4 is linked to glaucoma.