LAG3 and Miyoshi myopathy: In our study, for the first time, we focused on how anti-PD1 modifies the circulating EVs and their ability to affect the immune system, suggesting that in MM patients with innate resistance to anti-PD1, the exposure to ICI induced a reduction of the functionality of the T cells which became exhausted, as suggested by the increase of CD8+LAG3+PD1+ EVs, and by the reduction of the recruitment of DCs in TME.